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Post by Douglas on Oct 28, 2003 13:25:01 GMT -5
Is anyone out there an adult ADD/ADHD who is taking Strattera (a norepinephine reuptake inhibitor) IN COMBINATION WITH a seratonin reuptake inhibitor?
Is there any reason why this would not be useful to try?
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Post by mskris on Oct 29, 2003 9:44:34 GMT -5
Douglas:
This info is from the atomoxetine hydrochloride labeling:
CYP2D6 Inhibitors --Atomoxetine is primarily metabolized by the CYP2D6 pathway to 4-hydroxyatomoxetine. In Extensive Metabolizers, selective inhibitors of CYP2D6
increase atomoxetine steady-state plasma concentrations to exposures similar to those observed in Poor Metabolizers. Dosage adjustment of STRATTERA may be
necessary when coadministered with CYP2D6 inhibitors, e.g., paroxetine, fluoxetine, and quinidine. ( See DOSAGE AND ADMINISTRATION ) In Extensive Metabolizers
individuals treated with paroxetine or fluoxetine, the AUC of atomoxetine is approximately 6- to 8-fold and C ss,max is about 3- to 4-fold greater than
atomoxetine alone.
Thus, yes, there is an interaction potential between Strattera and SSRIs. You may have to lower the dose of Strattera.
Kris
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